ea0022p505 | Growth factors | ECE2010
Petakov Milan
, Suvajdzic Nada
, Petakov Marijana
, Macut Djuro
, Ognjanovic Sanja
, Elezovic Valentina
, Djurovic Marina
, Damjanovic Svetozar
Background/aims: Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues including liver. It has been shown that chronic diseases with liver involvement might cause IGF1 deficiency. The aim of the study was to assess the IGF1 system in adult patients with type 1 Gaucher disease with and without enzyme replacement therapy (...